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YMC-Triart C18 ExRS

YMC-Triart C18 ExRS is a high-coverage C18 phase based on organic/inorganic hybrid silica particles. The hydrophobicity of YMC-Triart C18 ExRS is high due to the high carbon loading (25%), which makes YMC-Triart C18 ExRS suitable for use with hydrophobic isomers and structural analogs. Given the superior chemical and physical durability of YMC-Triart C18 ExRS, chromatographers are afforded additional flexibility in choosing separation conditions for both method development and routine column usage.

To YMC-Triart Series
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SPECIFICATION

Base : organic/inorganic hybrid silica
Particle size : 1.9 µm, 3 µm, 5 µm
Pore size : 80Å
Carbon content : 25%
pH range : 1-12
USP class : L1

POINT

  • C18 phase with high density bonding on inorganic/organic hybrid silica gel
  • Excellent selectivity for isomers and structural analogs
  • Superior chemical durability (see Triart series for details of chemical durability)
  • Identical selectivity across different particle sizes

APPLICATION DATA



Comparison of fundamental separation selectivity

A mixture that consists of compounds with various characteristics is analyzed with Triart C18 and Triart C18 ExRS. Triart C18 ExRS has lower polarity and higher hydrophobicity than the standard Triart C18 column, and also shows improved shape recognition.

1. Amitriptyline (basic compound)
2. 8-Quinolinol (coordination compound)
3. Testosterone (polar compound)
4. Naphthalene (π-π interaction)
5. Ibuprofen (acidic compound)
6. Propylbenzene (hydrophobicity)
7. n-Butylbenzene (hydrophobicity)
8. o-Terphenyl (planar cognitive ability)
9. Triphenylene (planar cognitive ability)

Column : 5 µm, 150 X 3.0 mmI.D.
Eluent : 20 mM KH2PO4-H3PO4 (pH 3.1) /methanol (25/75)
Flow rate : 0.425 mL/min
Temperature : 40°C
Detection : UV at 265 nm
Injection : 4 µL

 

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Ideal for separation of structural analogs

Triart ExRS is effective for separating structural analogs. This feature is especially useful for separating pharmaceuticals with structurally similar impurities.


Vitamin D2 and Vitamin D3

 

Vitamin D2
(Ergocalciferol)
Vitamin D3
(Cholecalciferol)
Column : 5 µm, 150 X 3.0 mmI.D.
Eluent : THF/acetonitrile (10/90)
Flow rate : 0.425 mL/min
Temperature : 30ºC
Detection : UV at 265 nm
Injection : 4.25 µL (10 µg/mL)

 

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