Contract purification service

Supporting production of pharmaceuticals and functional materials with purification technology

YMC can support our customers’ production of pharmaceuticals and/or functional materials with our purification technologies, which we have accumulated over many years. Please feel free to contact us if chromatographic purification will be needed during the manufacturing of biopharmaceuticals, chiral compounds, impurities etc.

API Purification Plant for pharmaceuticals, which is compliant with GMP requirements, has also been established, and we have just started a full-scale contract purification service for high-value-added substances, including biopharmaceuticals. We can optimize methods, depending on the objective and required purity, and perform preparative purification using preparative LC systems and packing materials, developed and produced in-house.

In addition to ensuring qualification of target substances according to your request, we will also propose an efficient separation method that may result in a cost reduction, based on our past achievements and know-how.

Advantages of custom purification

Separation and purification using chromatography has high technology, time, and cost requirements. At YMC, we provide purification service using our accumulated experience, know-how, and excellent equipment.

Separation / purification chromatography

Are you having trouble?

Use of a service provided by YMC

  • Accumulated experiences and know-how of separation/purification
  • Low-cost columns and packing materials manufactured in-house
  • Availability of large columns and separation devices

Supply of high-purity compound
Quick service
High credibility
Low cost

Products and scale for purification

System Column inner diameter Scale Target substances
Preparative HPLC device 10-1000 mmI.D.
(Packed columns / Axial compression columns)
mg to ton
  • Active pharmaceutical ingredients (API)
  • Peptides
  • Oligonucleotides
  • Chiral compounds
  • Achiral compounds
LPLC device
(Bio-LC device)
10-1000 mmI.D.
(Glass / Acrylic columns)
mg to ton
  • Bio API
  • Oligonucleotides
  • Proteins, etc.
Continuous Chromatography System 4.6-50 mmI.D.
(Packed columns / Glass columns)
to g
  • Impurities
  • Active pharmaceutical ingredients (API)
  • Oligonucleotides
  • Peptides/Proteins, etc.

Purification example

Raw materials
(Peptides, oligonucleotides, etc)

Ion exchange chromatography

Ion exchange chromatography

Reversed-phase chromatography

Concentration and drying

Purified material
(~500 kg/year)

Steps for using a purification service

Purification request
  • Consultation
  • Signing a non-discloure agreement
  • Preliminary test, using customer-provided sample
Report for preliminary
test results
  • Suggestions of optimal column and purification methods
Submission of quotation
Actual purification
  • Purification with optimal methods
Delivery of the purified material and reports  

YMC worldwide network

Through YMC worldwide network, we secure our global supply chain and customer service. Our purification service will be soon available not only in Japan but also in Europe, the U.S. and India. We are also planning to increase our offices mainly in countries and regions where the pharmaceutical business is expected to grow.