Bulk packings

BioPro Series

BioPro and BioPro SmartSep, ion exchange media with high dynamic binding capacities and high recoveries, are suitable for downstream chromatographic purification processes in biopharmaceutical manufacturing. BioPro and BioPro SmartSep are suitable for initial purification (capture) and for intermediate to final purification (polishing), respectively.
YMC-BioPro, ion exchange columns with high resolution, are suitable for uniformity tests, such as isoform analysis in quality control and characterization of biopharmaceuticals.

Media

  BioPro Ion Exchange Media BioPro SmartSep
BioPro Q BioPro S BioPro DA BioPro CM BioPro SmartSep Q BioPro SmartSep S
Matrix Hydrophilic porous polymer
Particle size (μm) 75 60 10, 20, 30
Ion exchanger -R-N+(CH3)3 -R-SO3- -R-N(CH3)2 -R-COOH -R-N+(CH3)3 -R-SO3-
Feature Suitable for capture and intermediate purification step
High binding capacity
Suitable for intermediate purification step and polishing step
High-throughput purification by utilizing mechanical strength
polymer beads

BioPro Ion Exchange Screening Kit

        Available in four chemistries: Strong ion exchangers and weak ion exchangers
        For media screening, develop of purification method and loadability study

Column

  YMC-BioPro (packed column)
YMC-BioPro QA-F YMC-BioPro SP-F YMC-BioPro QA YMC-BioPro SP
Matrix Hydrophilic non-porous polymer Hydrophilic porous polymer
Particle size (μm) 3, 5 5
Ion exchanger -CH2N+(CH3)3 -CH2CH2CH2SO3- -CH2N+(CH3)3 -CH2CH2CH2SO3-
Feature For increasing resolution and throughput
High efficiency with low operating pressure
Suitable for characterization of biopharmaceuticals and quality control
Suitable for laboratory-scale purification
High binding capacity and high recovery of biomolecules

Products subjected to purification process of biopharmaceuticals

Process Required media performance BioPro products
Capture
  • High binding capacity in high flow rate
  • Excellent characteristic of pressure and flow rate realizing high flow rate
BioPro
(75, 60 μm)
Intermediate
  • High resolution to remove most of impurity
  • High binding capacity
  • Easy to scale up
  • Excellent mechanical strength and pressure resistance
BioPro SmartSep
(10, 20, 30 μm)
Polishing
  • Quite high performance to separate impurities whose retention time close to each other
  • Low nonspecific binding capacity
Analytical
  • High resolution and excellent lot-to-lot reproducibility
YMC-BioPro
(packed column)