For cost-effective chiral preparation
Chromatography using chiral stationary phases (packing materials) is one effective method that is used as a standard method for chiral preparation, but purification cost is a problem for industrial-scale purification owing to the high cost of the stationary phase. YMC has developed high performance packed materials, packed columns, and preparative HPLC devices corresponding to various scales, from microanalysis to large preparations, as products for chromatography, mainly for achiral separations. In the field of chiral technology, we are attempting to reduce the cost of chiral separation by proposing optimal column selection, high-efficiency preparative methods, and purification contract services based on our past achievements and know-how.
CHIRAL ART are HPLC column/packing materials with polysaccharide derivatives chiral selector. CHIRAL ART are suitable for the separation of a wide range of chiral compounds, cis-trans isomers, and geometric isomers. CHIRAL ART are available in HPLC columns and in preparative grades, in large (multi kg) quantities.
K-Prep is a preparative chromatographic device applicable from laboratory scale to industrial scale. Fully automatic operation by PC is possible. Dynamic axial compression columns with automatic self-packing are also available. They can be designed depending on customer needs (suitability for GMP and explosion-proof design).
Recycling chromatography can realize high resolution by running a sample through the column repetitively, even if a short column is used. Because of this, it can be used for purification of difficult to separate samples and to save solvent in the case of large-scale purification. LC Forte/R-II is compact enough for bench-top installation and can easily purify several grams of chiral compounds in a day.
YMC established Chiral Technologies Laboratory (an existing Kyoto Research Laboratories) in Kyoto in 2013, and has also started a contract separation service for isolating optical isomers. Komatsu Works can conduct chiral compound purification depending on the requested scale, from small- to large-scale production, by using large facilities for preparative purification.